Further Trials of Live Influenza Vaccine

Trials of Live Influenza Vaccine in the Royal Air Force.

evidence of enlargement of the main pulmonary artery were assessed in all. We attempted to assess changes in the peripheral pulmonary arterial branches as recommended by Davies, Goodwin, Steiner, and Van Leuven (1953), but found in many cases this was too difficult to determine with sufficient certainty. The three criteria we have used (pulmonary hypertension, E.C.G. signs of right ventricular ...

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Phase I clinical trials of safety and immunogenicity of live cultural influenza vaccine vector-flu

Background Live influenza vaccines trigger all major components of the anti-flu immune response machinery and have been included in the global WHO program on the pandemic preparedness. Key advantages of using live vaccines include a feasibility of intranasal administration, opportunity to rapidly scale up production of the viral substance, simplicity of vaccination, and robust protection agains...

Live attenuated influenza vaccine--a review.

Owing to the variability of influenza viruses, vaccine composition needs to be up-dated annually. As many variables can influence their efficacy, vaccines are still considered "sub-optimal". Many studies have been carried out in recent years to improve vaccines. In particular, researchers and vaccine-producing corporations have focused on developing a live vaccine. Among the candidate vaccines,...

Safety and immunogenicity of live attenuated influenza reassortant H5 vaccine (phase I–II clinical trials)

OBJECTIVE Our studies aimed to evaluate in clinical trials the safety and immunogenicity of an H5 live influenza vaccine candidate obtained using classical reassortment techniques from a low pathogenicity avian influenza (LPAI) A/Duck/Potsdam/1402-6/86(H5N2) virus and the cold-adapted (ca) donor strain A/Leningrad/134/17/57(H2N2). METHODS During Phase I-II clinical trials, volunteers received...